PPARδ agonist 11

SKU: orb2665100

Description

Compound 11 is a potent and selective PPARδ agonist (EC50 = 20 nM) with demonstrated anti-inflammatory effects in vitro, suppressing NO, TNFα, and IL-6 via NF-κB in LPS-stimulated macrophages. It shows high metabolic stability, excellent oral bioavailability (~100%), and effectively reduces carrageenan-induced foot edema in vivo, making it a valuable tool for metabolic and inflammatory disease research.

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2982696-04-6
• MW: 440.46
• Formula: C₁₉H₁₅F₃N₂O₃S₂
• SMILES: O=C(O)COC1=CC=C(SCC2=NN=C(S2)C=3C=CC(=CC3)C(F)(F)F)C=C1C
• Target: PPAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138454901