PP58

SKU: orb1707865

Description

PP58 is a small molecule inhibitor targeting platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR), and Src family kinases. It is a research tool used in vitro and in vivo to study signaling pathways in oncology and angiogenesis.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 212391-58-7
• MW: 456.32
• Purity: 99.62% (May vary between batches)
• Formula: C₂₂H₁₉Cl₂N₅O₂
• SMILES: Cn1c2nc(Nc3ccc(OCCN)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
• Target: Src,TNF,p38 MAPK,PDGFR,FGFR
• Solubility: DMSO:56.3 mg/mL (123.38 mM)

Bioactivity

• In Vivo:
  PP58 exhibits some degree of selectivity in vivo.
• In Vitro:
  PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FGFR, Src, TNF-α, PP 58, PP58, PP-58, p38 MAPK, p38MAPK, p38, PDGFR

Compound Identifiers

PubChem CID

5327904