PP 242

SKU: orb1227008

Description

A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively; shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM); blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.

Key Properties

• CAS Number: 1092351-67-1
• MW: 308.3378
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₆N₆O
• SMILES: OC1=CC2=C(NC(C3=NN(C(C)C)C4=NC=NC(N)=C43)=C2)C=C1
• Target: mTOR
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PP242 | PP-242

Quick Database Links

Gene Symbol

mTOR