Poricoic acid B

SKU: orb1297598

Description

Poricoic acid B is a bioactive small molecule that inhibits TPA-induced inflammatory edema in vivo and suppresses Epstein-Barr virus early antigen activation in vitro. This compound is a useful research tool for studying inflammation and viral oncogenesis pathways.

Key Properties

• CAS Number: 137551-39-4
• MW: 484.67
• Purity: 98.99% (May vary between batches)
• Formula: C₃₀H₄₄O₅
• SMILES: CC(C)=CCC[C@H]([C@H]1[C@H](O)C[C@@]2(C)C3=CC[C@@H](C(C)=C)[C@](C)(CCC(O)=O)C3=CC[C@]12C)C(O)=O
• Target: Others
• Solubility: DMSO:22.5 mg/mL (46.42 mM)

Bioactivity

• In Vitro:
  These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Poricoic acid B, Inhibitor, inhibit

Compound Identifiers

PubChem CID

5471852