Porcn-IN-1

SKU: orb1302860

Description

Porcn-IN-1

Research Area

Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2036044-77-4
• MW: 410.44
• Purity: 99.61% (May vary between batches)
• Formula: C₂₅H₁₉FN₄O
• SMILES: Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F
• Target: Porcupine
• Solubility: DMSO:100 mg/mL (243.64 mM)

Bioactivity

• Target IC50:
  Porcupine:0.5 Nm
• In Vivo:
  Porcupine-IN-1 exhibits moderate metabolic clearance in human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg), while demonstrating high clearance rates in mouse liver microsomes (109 mL/min/kg).
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• In Vitro:
  Porcupine, an enzyme, facilitates the attachment of palmitoleate to a serine residue within Wnt proteins, essential for their secretion. Porcupine-IN-1 exhibits potency comparable to the clinical compound LGK974 in a cell-based STF reporter gene assay and effectively inhibits the secretion of Wnt3A, thereby confirming its role as a porcupine inhibitor.
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• Cell Research:
  HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Porcn, Porcupine-IN-1, Porcn IN 1, PorcnIN1, Porcn-IN-1, Porcupine

Compound Identifiers

PubChem CID

132578555