POP-3MB

SKU: orb2565447

Description

POP-3MB (compound 1b) is a potent ICMT inhibitor with an IC50 of 2.5 µM. It disrupts K-Ras membrane localization, suppresses Ras activation, and blocks downstream Erk phosphorylation. This tool compound is valuable for studying Ras-driven oncogenesis in both cellular and animal models of cancer.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1144114-27-1
• MW: 605.79
• Formula: C₃₈H₃₉NO₄S
• SMILES: O(C1=C(C(N[C@@H](CSCC=C(CCC2=CC=C(C=C2)C3=CC=CC=C3)CC=C(C)C)C(O)=O)=O)C=CC=C1)C4=CC=CC=C4
• Target: Transferase,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419012