PON-PC

SKU: orb2283257

Description

PON-PC, an oxidized phospholipid with a 9-carbon fatty acyl chain ending in an aldehyde at the sn-2 position, arises from the oxidation of palmitoyl oleoyl phosphatidylcholine (POPC) or through interaction with ozone in pulmonary surfactant. It is found in oxidized LDL. At a 40 µM concentration, PON-PC diminishes the production of TNF-α, nitric oxide (NO), and NADP+ in primary mouse alveolar macrophages and lowers the bactericidal capability of RAW 264.7 cells. Additionally, levels of PON-PC increase in the bronchoalveolar lavage fluid (BALF) of mice exposed to cigarette smoke or in older mice.

Key Properties

• CAS Number: 135726-46-4
• MW: 649.4
• Formula: C₃₃H₆₄NO₉P
• SMILES: [C@@H](COP(OCC[N+](C)(C)C)(=O)[O-])(OC(CCCCCCCC=O)=O)COC(CCCCCCCCCCCCCCC)=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

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