Pomalidomide-PEG4-Ph-NH2

SKU: orb1299535

Description

This synthetic conjugate features a pomalidomide-based cereblon ligand connected via a tetraethylene glycol (PEG4) linker, terminating in a phenylamine group. It serves as a key component in the development of PROTACs for targeted protein degradation, a technique widely applied in both in vitro and in vivo cancer and disease mechanism research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1818885-63-0
• MW: 540.57
• Purity: 99.49% (May vary between batches)
• Formula: C₂₇H₃₂N₄O₈
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOC4=CC=C(N)C=C4
• Target: E3 Ligase Ligand-Linker Conjugates,Ligands for E3 Ligase
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:50 mg/mL (92.49 mM)

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, LigandforE3Ligase, Ligand for E3 Ligase, E3 Ligase Ligand Linker Conjugates 2, E3 Ligase Ligand-Linker Conjugates, E3 Ligase LigandLinker Conjugates 2, E3 Ligase Ligand-Linker Conjugates 2, Cereblon Ligand-Linker Conjugates 9, Pomalidomide-PEG4-Ph-NH2

Compound Identifiers

PubChem CID

118435234