Pomalidomide-PEG4-C2-NH2 hydrochloride

SKU: orb1303319

Description

Pomalidomide-PEG4-C2-NH2 hydrochloride is a PROTAC linker featuring a PEG spacer, utilized in constructing proteolysis-targeting chimeras for targeted protein degradation research. This compound is applied in both in vitro and in vivo studies to develop novel therapeutics, particularly in oncology and disease models involving aberrant protein signaling.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2357105-92-9
• MW: 528.98
• Purity: 98.18%
• Formula: C₂₃H₃₃ClN₄O₈
• SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN)=O.[H]Cl
• Target: E3 Ligase Ligand-Linker Conjugates,PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, E3 Ligase Ligand-Linker Conjugates, PomalidomidePEG4C2NH2 hydrochloride, Pomalidomide-PEG4-C2-NH2 Hydrochloride, Pomalidomide PEG4 C2 NH2 hydrochloride, PEGs, PROTACLinker, PROTAC Linker

Compound Identifiers

PubChem CID

138695332