Pomalidomide-methylamino-PEG1-NH2 hydrochloride

SKU: orb2813939

Description

This compound serves as a versatile building block for PROTAC and molecular glue development, featuring a CRBN-binding pomalidomide moiety connected via a PEG linker to a terminal amine. The reactive amine enables conjugation to target warheads, facilitating the creation of bifunctional degraders for both in vitro and in vivo target validation studies.

Research Area

Pharmacology & Drug Discovery, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• MW: 481.93
• Formula: C₂₁H₂₈ClN₅O₆
• SMILES: O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCN(CCOCCN)C.[H]Cl
• Target: Ligands for Target Protein for PROTAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171329206