Pomalidomide-amino-PEG3-NH2 hydrochloride

SKU: orb1984568

Description

Pomalidomide-amino-PEG3-NH2 hydrochloride is a cereblon E3 ligase ligand conjugated to a triethylene glycol linker. This conjugate serves as a key intermediate for constructing PROTAC degraders, which are widely used in chemical biology and oncology research for targeted protein degradation in vitro.

Research Area

Pharmacology & Drug Discovery, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 2380273-75-4
• MW: 498.91
• Purity: 98.87% (May vary between batches)
• Formula: C₂₁H₂₇ClN₄O₈
• SMILES: Cl.O=C(NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COCCOCCOCCN
• Target: E3 Ligase Ligand-Linker Conjugates,Ligands for E3 Ligase
• Solubility: DMSO:80 mg/mL (160.35 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands linked by a linker: one ligand binds to the E3 ubiquitin ligase, and the other ligand binds to the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to achieve selective degradation of the target protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, Pomalidomide amino PEG3 NH2 hydrochloride, PomalidomideaminoPEG3NH2 hydrochloride, Pomalidomide-amino-PEG-3-NH2 hydrochloride

Compound Identifiers

PubChem CID

139034677