Polyporenic acid C

SKU: orb1297524

Description

Polyporenic acid C is a bioactive small molecule that acts as a human collagenase inhibitor. This compound is utilized in biochemical research to study extracellular matrix remodeling, with applications in investigating connective tissue disorders and related in vitro enzymatic assays.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 465-18-9
• MW: 482.69
• Purity: 99.71% (May vary between batches)
• Formula: C₃₁H₄₆O₄
• SMILES: [H][C@]1([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@@]2(C)C3=CC[C@@]4([H])C(C)(C)C(=O)CC[C@]4(C)C3=CC[C@]12C
• Target: Caspase|||PI3K|||Apoptosis|||PARP
• Solubility: DMSO:60 mg/mL (124.3 mM)

Bioactivity

• In Vitro:
  Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, lung, PARP, NSCLC, Apoptosis, Caspase, cancer, cell, Polyporenic acid C, PI3K

Compound Identifiers

PubChem CID

9805290