Polyphyllin I

SKU: orb1222153

Description

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

Key Properties

• CAS Number: 50773-41-6
• MW: 855.03
• Purity: >98% (HPLC)
• Formula: C₄₄H₇₀O₁₆
• SMILES: [C@@H]1([C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O)O[C@@H]1O[C@H]([C@@H]([C@H]1O)O)CO)CO)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)CC[C@H](CO6)C
• Target: NF-κB
• Solubility: In Vitro: DMSO : 100 mg/mL (116.96 mM)

Bioactivity

• In Vivo:
  Animal model: BALB/c nude mice (5 weeks old) were s. c. inoculated with A549 cells. Dosage: 1.5 mg/kg. Administration: i.p. twice daily from day 2 to day 11. Result: The tumor growth rate was much lower than that in cisplatin group and PBS group.
• In Vitro:
  Cell Proliferation Assay Cell line: A549, H460, and SK-MES-1 cells. Concentration: 24, 48, 72 hours. Incubation time: 24, 48, 72 hours. Result: Markedly reduced proliferation capacity in vitro and in a concentration-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB