Polyoxyethylene stearate

SKU: orb1307860

Description

Polyoxyethylene stearate (POES) is a non-ionic surfactant commonly used to stabilize emulsions in biochemical research. It is applied in both in vitro and in vivo studies, including drug delivery formulations and as an excipient in nanoparticle synthesis for biomedical applications.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 9004-99-3
• Purity: polymer
• Formula: C₂₀H₄₀O₃
• SMILES: O=C(OCCO)CCCCCCCCCCCCCCCCC.[n].[n].[=].[10]
• Target: Antibacterial,P-gp
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL;DMSO:45 mg/mL

Bioactivity

• In Vivo:
  In the combination of polyoxyethylene 40 stearate and vinblastine, there is a significant reduction in both the average tumor volume and weight compared to the vinblastine group alone. The tumor growth inhibition rate markedly increases from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). Furthermore, polyoxyethylene stearate shows potential as a pharmaceutical excipient to enhance the oral bioavailability of drugs that are substrates for P-glycoprotein (P-gp) and certain cytochrome P450 (CYP) isoforms .
• In Vitro:
  Polyoxyethylene stearate modulates P-gp ATPase activity in a concentration-dependent manner, reducing P-gp mediated efflux, notably enhancing the efficacy of substances like vinblastine sulfate by limiting their expulsion from cells. This compound is also recommended to augment the radiolabelled 7H12 Middlebrook TB media, significantly promoting mycobacterial growth in the BACTEC rapid culture system. Its effectiveness extends across various mycobacterial species beyond M. tuberculosis. Specifically, at concentrations of 100 or 150 μg/mL, polyoxyethylene 40 stearate substantially increases the cytotoxicity of vinblastine to K562/ADR cells. Moreover, polyoxyethylene (50) stearate markedly boosts mycobacterial growth rates and decreases detection times in cultures, illustrating its broad potential in enhancing antimicrobial and chemotherapeutic treatments.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Multidrug resistance protein 1, MDR1, Inhibitor, ABCB1, Bacterial, CD243, Cluster of differentiation 243, Polyoxyethylene Stearate, Polyoxyethylene stearate, POES, P-glycoprotein, Pgp, P-gp (P-glycoprotein), P-gp

Quick Database Links

Gene Symbol

Antibacterial,P-gp