Polymyxin B sulfate

SKU: orb1226347

Description

Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.(In Vitro):Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.(In Vivo):Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model.Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080.

Key Properties

• CAS Number: 1405-20-5
• MW: 1301.56
• Purity: >98% (HPLC)
• Formula: C₅₆H₁₀₀N₁₆O₁₇S
• SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
• Target: Others
• Solubility: Water: 25 mg/mL

Bioactivity

• In Vivo:
  Polymyxin B Sulfate (0.5-120 mg/kg; s. c.) shows antibacterial activities in thigh or lung infection mouse model. Polymyxin B Sulfate (2 mg/kg, s. c.) shows potent in mouse bactericidal effect against E. coli strain IH3080. Animal model: Eight-week-old, 24-30 g, female Swiss mice. Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection mode. Administration: S. c. Result: Showed antibacterial activities for three K. pneumoniae strains. Animal model: 7-9 weeks, female NMRI mice (E. coli IH3080). Dosage: 2 mg/kg. Administration: S. c. Result: Decreased the bacterial count in a dose dependent manner.
• In Vitro:
  Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aerosporin | Mastimyxin

Quick Database Links

Gene Symbol

Others