Polygodial

SKU: orb1305705

Description

Polygodial (Tadeonal) is a sesquiterpene dialdehyde that acts as an antifungal potentiator and antibiotic, notably against Saccharomyces cerevisiae and Candida species. Its mechanism, studied in vitro, involves membrane disruption and synergy with conventional antifungals, making it a valuable tool for antimicrobial resistance research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 6754-20-7
• MW: 234.33
• Purity: 98.74%
• Formula: C₁₅H₂₂O₂
• SMILES: [H][C@@]12CC=C(C=O)[C@H](C=O)[C@@]1(C)CCCC2(C)C
• Target: Antifungal
• Solubility: DMSO:65 mg/mL (277.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.53 mM)

Bioactivity

• In Vivo:
  Polygodial (0.1 to 10 mg kg(-1), i.p.) produced significant inhibition of acetic acid, kaolin and zymosan-induced writhing in mice, being about 14 to 27-fold more potent than the hydroalcoholic extract at the ID50 level.
• In Vitro:
  When tested on S. cerevisiae, polygodial proved to be fungicidal rather than fungistatic. When the cells of S. cerevisiae are treated in vitro with polygodial for 10 min, the cell membrane becomes severely damaged, and many vesicles, possibly formed from the fragmented cell membrane, can be observed within the cytoplasm.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifungal,Potentiator,sesquiterpene,anti-hyperalgesic, Antifungal, inhibit, Inhibitor, Fungal, Poligodial, Polygodial, Tadeonal

Compound Identifiers

PubChem CID

72503