polygalaxanthone III

SKU: orb1693289

Description

Polygalaxanthone III is a potent and selective inhibitor of CYP2E1, effectively blocking the 6-hydroxylation of chlorzoxazone in vitro. This makes it a valuable chemical probe for studying CYP2E1-mediated metabolism, drug interactions, and toxicity mechanisms in hepatic research models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 162857-78-5
• MW: 568.48
• Purity: 99.74%
• Formula: C₂₅H₂₈O₁₅
• SMILES: COc1cc2c(cc1O)oc1cc(O)c([C@@H]3O[C@H](CO[C@@H]4OC[C@](O)(CO)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)c(O)c1c2=O
• Target: Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.52 mM);DMSO:60 mg/mL (105.54 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

polygalaxanthone III, Inhibitor, inhibit, CYPs, Cytochrome P450

Compound Identifiers

PubChem CID

11169063