Polygalasaponin F

SKU: orb1303694

Description

Polygalasaponin F is a research compound with demonstrated anti-neuroinflammatory properties, inhibiting LPS-induced TNF-α, NO, and iNOS via NF-κB. It protects neuronal PC12 cells from microglial-mediated cytotoxicity in vitro and enhances synaptic plasticity in the rat hippocampus in vivo through NMDAR/CaMKII/ERK/CREB signaling pathways.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 882664-74-6
• MW: 1091.24
• Purity: 99.75%
• Formula: C₅₃H₈₆O₂₃
• SMILES: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC(=O)[C@]23CCC(C)(C)C[C@H]2C2=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@@]4(C)[C@]2(C)CC3)[C@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
• Target: Akt,NF-κB,PI3K,TLR
• Solubility: DMSO:60 mg/mL (54.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.83 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Akt, Inhibitor, inhibit, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NFkB, NF-kB, Polygalasaponin F, Phosphoinositide 3-kinase, PI3K, TLR, PKB, Toll-like Receptor (TLR), Protein kinase B

Compound Identifiers

PubChem CID

11629473