Polθ/PARP-IN-1

SKU: orb3133842

Description

Polθ/PARP-IN-1 (compound 25d) is a potent dual inhibitor of DNA polymerase theta (Polθ) and PARP, with IC50 values of 45.6 nM and 5.4 nM, respectively. This compound exhibits antiproliferative activity, induces apoptosis and cell cycle arrest at the G2/M phase, leading to DNA damage, and demonstrates antitumor properties.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology

Key Properties

• Formula: C₃₈H₃₃ClFN₇O₅S
• Target: Apoptosis,DNA/RNA Synthesis,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,DNA/RNA Synthesis,PARP