Polmacoxib

SKU: orb1306413

Description

Polmacoxib (CG 100649) is a novel dual carbonic anhydrase and COX-2 inhibitor. It has demonstrated efficacy in suppressing premalignant and malignant colorectal lesions in mouse models, partly by inhibiting tumor cell proliferation, highlighting its research utility in oncology and inflammation studies.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 301692-76-2
• MW: 361.39
• Purity: 98.49% (May vary between batches)
• Formula: C₁₈H₁₆FNO₄S
• SMILES: CC1(C)OC(=C(C1=O)c1cccc(F)c1)c1ccc(cc1)S(N)(=O)=O
• Target: COX,Carbonic Anhydrase
• Solubility: H2O:Insoluble;DMSO:55 mg/mL (152.19 mM)

Bioactivity

• Target IC50:
  COX-2:0.1 μg/mL (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX-2, CG100649, CG-100649, CG 100649, colorectal, COX, Carbonate dehydratase, Carbonic Anhydrase, carbonic anhydrase, CarbonicAnhydrase, adenoma, inflammatory, NSAID, inhibit, Inhibitor, tumor, polyp, Polmacoxib, orthotopic

Compound Identifiers

PubChem CID

9841854