POL1-IN-1

SKU: orb1302922

Description

POL1-IN-1 (Compound 3A) is a selective RNA polymerase I transcription inhibitor, active in A375 melanoma cells in vitro without affecting RNA polymerase II. This specificity makes it a valuable chemical probe for studying nucleolar stress and ribosome biogenesis in cancer research models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1822358-25-7
• MW: 356.42
• Purity: 98.01% (May vary between batches)
• Formula: C₂₁H₂₀N₆
• SMILES: C(#N)C=1C=2N(C=3C(C1)=CC=C(N3)N4C[C@@H](C)N[C@@H](C)C4)C=5C(N2)=CC=CC5
• Target: DNA/RNA Synthesis
• Solubility: DMSO:3.57 mg/mL (10.02 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, POL1 IN 1, POL1IN1, POL-1-IN-1, POL1-IN-1, inhibit, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, cell, Compound 3A, cancer, RNASynthesis, RNA polymerase I, RNA Synthesis, transcription, proliferation

Compound Identifiers

PubChem CID

118509873