Polθ-IN-3

SKU: orb2564568

Description

Polθ-IN-3 (Compound 113) is an orally bioavailable, small-molecule inhibitor of DNA Polymerase Theta. It demonstrates antitumor efficacy in research models, making it a valuable tool for studying DNA repair pathways, synthetic lethality, and cancer biology in both cellular and animal studies.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 2922287-81-6
• MW: 507.52
• Formula: C₂₄H₁₉F₂N₇O₂S
• SMILES: O=C(NC1=NN=C(C#CC2CC2)S1)C=3C=NC(=CC3C4=CC(=NC=C4OC)C(F)F)C5=NN(C=C5)C
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171490645