Polθ-IN-10

SKU: orb3210457

Description

Polθ-IN-10 is an inhibitor of Polθ-pol with a human IC50 of 1.3 nM, and it exhibits oral bioavailability in both mice and rats. It binds to an allosteric site on Polθ-pol, disrupting the microhomology-mediated end joining DNA repair pathway, and inhibits CYP2C9 with an IC50 of 1.63 μM. Polθ-IN-10 selectively inhibits the proliferation of HR-deficient cancer cells and induces apoptosis. This compound is suitable for research on HR-deficient cancers.

Key Properties

• CAS Number: 3068829-46-6
• MW: 556.51
• Formula: C₂₇H₂₄F₄N₆O₃
• SMILES: C(N(CC#CC1=CC=C(C(C)(C)O)N=N1)C2=CC=C(F)C=C2)(=O)[C@H]3N(C(=O)NC3)C4=CC(C(F)(F)F)=CC(C)=N4
• Target: Cytochromes P450,DNA/RNA Synthesis,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Cytochromes P450,DNA/RNA Synthesis,Apoptosis