Podocarpusflavone A

SKU: orb1679043

Description

Podocarpusflavone A

Research Area

Cell Biology, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 22136-74-9
• MW: 552.48
• Purity: 99.90%
• Formula: C₃₁H₂₀O₁₀
• SMILES: COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1
• Target: Topoisomerase,Apoptosis,STAT
• Solubility: DMSO:40 mg/mL (72.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.81 mM)

Bioactivity

• Target IC50:
  Topo I:119.425 μM IC50 |FASN:24.08
• In Vivo:
  Podocarpusflavone A was administered daily to A375 cell-derived xenograft mice (20, 40 mg/kg, po, for 21 days), and Podocarpusflavone A significantly suppressed tumor size and weight in xenograft mice.
• In Vitro:
  Podocarpusflavone A showed significant Inhibition against KB, DLD, HEp-2, MCF-7 tumour cell lines (ED50 4.56-16.24 μg/ml). It induced cell apoptosis in MCF-7 mainly via sub-G1/S phase arrest. PF (40 ug/mL, 24 hours) induced a significant increase in cell death and growth arrest in the S phase by about 10-fold compared to the control group Podocarpusflavone A (0,5,10,20 μM) treatment of four melanoma cell lines (A375, Malme-3M, SK-MEL-1, and SK-MEL5) for 24 h significantly inhibited p-STAT3 levels, but not total STAT3 protein levels, in All cell lines tested. In addition, a dose-dependent Inhibition of p-STAT3 expression was observed In both A375 and SK-MEL-1 cells an the IC50 Values were approximately 10 μM for both A375 and SK-MEL-1 cells

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Podocarpusflavone A, Topo I, STAT3

Compound Identifiers

PubChem CID

5320644