PNU112455A hydrochloride

SKU: orb1299104

Description

PNU112455A hydrochloride is a competitive ATP-binding site inhibitor of CDK2 and CDK5, exhibiting K_m values of 3.6 µM and 3.2 µM, respectively. This small molecule is a research tool for studying cell cycle regulation and neuronal function in vitro, with applications in oncology and neurodegenerative disease research.

Research Area

Cell Biology

Key Properties

• CAS Number: 21886-12-4
• MW: 301.75
• Purity: >99.99% (May vary between batches)
• Formula: C₁₀H₁₂ClN₅O₂S
• SMILES: Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1
• Target: CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.26 mM);DMSO:125 mg/mL (414.25 mM)

Bioactivity

• Target IC50:
  CDK5:3.2 μM (Km)|CDK2:3.6 μM (Km)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

site, PNU112455A, PNU-112455A hydrochloride, PNU 112455A, PNU 112455A HCL, anticooperative, ATP, Alzheimer's, CDK

Compound Identifiers

PubChem CID

16760362