PNU-EDA-Gly5

SKU: orb1691359

Description

PNU-EDA-Gly5 is a conjugate comprising the potent topoisomerase I inhibitor PNU-159682 linked via an EDA-Gly5 spacer, designed for constructing antibody-drug conjugates (ADCs). This payload-linker system is utilized in ADC research for targeted cancer therapy, demonstrating potent antitumor activity in both in vitro and in vivo experimental models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1957223-28-7
• MW: 954.944
• Formula: C₄₃H₅₄N₈O₁₇
• SMILES: [H][C@]12C[C@H](O[C@H]3C[C@@](O)(Cc4c(O)c5C(=O)c6cccc(OC)c6C(=O)c5c(O)c34)C(=O)NCCNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN)O[C@@H](C)[C@@]1([H])O[C@]1([H])[C@@H](OC)OCCN21
• Target: Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162641686