Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

PNU-74654

SKU: orb1226929

Description

A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM, significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.

Images & Validation

Key Properties

CAS Number113906-27-7
MW320.34194
Purity>98% (HPLC)
FormulaC19H16N2O3
SMILESO=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3
TargetBeta-catenin
SolubilityDMSO: ≥ 30 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PNU74654 | PNU 74654

Similar Products

  • PNU 74654 [orb1299981]

    >98%

    113906-27-7

    320.35

    C19H16N2O3

    5 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

500 mg
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 250.00
50 mg
$ 460.00
100 mg
$ 810.00
200 mg
$ 1,160.00