PNU-282987 free base

SKU: orb1689586

Description

PNU-282987 free base is a selective α7 nAChR agonist and 5-HT3 antagonist with demonstrated anti-inflammatory effects. It has been studied in models of sepsis-induced lung injury and airway inflammation, showing protective activity. This compound is a valuable research tool for investigating neurological and inflammatory diseases.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 711085-63-1
• MW: 264.75
• Purity: 99.64% (May vary between batches)
• Formula: C₁₄H₁₇ClN₂O
• SMILES: Clc1ccc(cc1)C(=O)N[C@H]1CN2CCC1CC2
• Target: AChR|||5-HT Receptor

Bioactivity

• In Vivo:
  In Rats, PNU-282987 free base ( 1,3 mg/kg ; i.v. ) can significantly reversed amphetamine-induced gating deficit.
• In Vitro:
  PNU-282987 is an agonist of α7 neuronal nicotine receptor ( EC50 = 154 n M ) and an inhibitor of 5-HT3 receptor ( IC50 = 4541 n M ).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HT Receptor, 5-HT3, 5HTReceptor, α7 nAChR

Compound Identifiers

PubChem CID

9795278