PLX-8394

SKU: orb1226376

Description

A potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23 nM for BRaf V600E/BRAF/CRAF, respectively; shows pERK inhibition in A375 and COLO829 cells with IC50 of 3.5 nM and 2.1 nM, respectively; and do not elicit paradoxical ERK1/2 activation in mutant RAS expressing cells; exhibits effectivity in both BRAFV600E and certain non-V600 LA models, in vitro and in vivo.Skin Cancer Phase 2 Clinical.

Key Properties

• CAS Number: 1393466-87-9
• MW: 542.5328
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₁F₃N₆O₃S
• SMILES: O=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O
• Target: Raf
• Solubility: DMSO: ≥ 39 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PLX 8394

Quick Database Links

Gene Symbol

Raf