Pluripotin

SKU: orb1300320

Description

Pluripotin (SC1) is a dual inhibitor of ERK1 (MAPK3) and RasGAP that promotes embryonic stem cell (ESC) self-renewal. It is widely used in stem cell research to maintain pluripotency in vitro and has been applied in studies investigating signaling pathways crucial for development and regeneration.

Research Area

Signal Transduction

Key Properties

• CAS Number: 839707-37-8
• MW: 550.53
• Purity: 98.82% (May vary between batches)
• Formula: C₂₇H₂₅F₃N₈O₂
• SMILES: CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
• Target: Raf,S6 Kinase,ERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.63 mM);DMSO:13.8 mg/mL (25.07 mM)

Bioactivity

• Target IC50:
  ERK1:98 nM(Kd)|RSK2:2.5 μM|RSK1:0.5 μM|RSK4:10 μM|RSK3:3.3 μM|RasGAP:212 nM(Kd)
• In Vitro:
  Pluripotin is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for Pluripotin's effects on mES cells. Pluripotin activates Ras by inhibition of RasGAP function. Pluripotin improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with Pluripotin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Pluripotin, ERK, ERK1, Extracellular signal regulated kinases, SC1, SC-1, SC 1, S6Kinase, S6 Kinase, S6K, Ribosomal S6 Kinase (RSK), RasGAP

Compound Identifiers

PubChem CID

12003241