Plumbagin

SKU: orb1222203

Description

Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.(In Vitro):Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.(In Vivo):Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.

Key Properties

• CAS Number: 481-42-5
• MW: 188.18
• Purity: >98% (HPLC)
• Formula: C₁₁H₈O₃
• SMILES: CC1=CC(=O)c2c(C1=O)cccc2O
• Target: ROS
• Solubility: DMSO : ≥ 150 mg/mL 797.11 mM H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: Male athymic nude mice bearing DU145 cells. Dosage: 2 mg/kg. Administration: i.p. after 3 days post cell implantation, five days a week. Result: Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.
• In Vitro:
  Apoptosis Analysis Cell line: DU145, CWR22rv1, LNCaP and RWPE-1 cells. Concentration: 0, 5, 10, and 15 μM. Incubation time: 24 hours. Result: Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Plumbagin

Quick Database Links

Gene Symbol

ROS