PLK1/BRD4-IN-1

SKU: orb1685981

Description

PLK1/BRD4-IN-1 (9b) is a potent, orally bioavailable dual inhibitor targeting PLK1 and BRD4 with IC50 values of 22 nM and 109 nM, respectively. It demonstrates significant anti-tumor activity in vivo, making it a valuable chemical probe for oncology research, particularly in studying cell cycle progression and epigenetic regulation in cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 2412707-81-2
• MW: 573.73
• Formula: C₃₁H₄₃N₉O₂
• SMILES: C(N1C=2C(N3C([C@H]1CC)=NN=C3C)=CN=C(NC4=C(OC)C=C(C(NC5CCN(C)CC5)=O)C=C4)N2)C6CCCCC6
• Target: Others,c-Myc,Androgen Receptor,PLK,Apoptosis,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156775102