PLK1-IN-16

SKU: orb3210279

Description

PLK1-IN-16 is a selective inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 0.25 nM. It exhibits lower inhibitory activity against PLK2 and PLK3, induces G2 phase cell cycle arrest, and triggers apoptosis (apoptosis), showing antiproliferative activity in tumor cells. The compound is stable under simulated gastric acid conditions and has an acceptable level of CYP 450 inhibition. PLK1-IN-16 is applicable for research in triple-negative breast cancer (TNBC), breast cancer, and leukemia.

Key Properties

• CAS Number: 3068378-51-5
• MW: 526.65
• Formula: C₂₆H₃₄N₆O₄S
• SMILES: C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C4C(=C3)CCN4S(=O)(=O)C5CC5)N2)C6CCCC6
• Target: PLK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PLK,Apoptosis