PLK1-IN-13

SKU: orb3028536

Description

PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3038489-48-1
• MW: 577.744
• Formula: C₂₉H₃₉N₉O₂S
• SMILES: C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C=C3)C=4SC(CN5CCN(C)CC5)=NN4)N2)C6CCCC6
• Target: PLK,Apoptosis,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PLK,Apoptosis,c-Myc