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Plinabulin
Catalog Number: orb1305375
| Catalog Number | orb1305375 |
|---|---|
| Category | Small Molecules |
| Description | Plinabulin |
| CAS Number | 714272-27-2 |
| Purity | 91.68% |
| MW | 336.39 |
| SMILES | C(\C1=C(C(C)(C)C)N=CN1)=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2 |
| Formula | C19H20N4O2 |
| Biological Activity | Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
- Item 1 of 1
Plinabulin [orb1224168]
> 98%(HPLC)
714272-27-2
100 mg, 50 mg, 1 g, 500 mg, 200 mg, 25 mg, 10 mg, 5 mg, 2 mg
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