PLH1215

SKU: orb1819112

Description

PLH1215 is a potent aryl hydrocarbon receptor (AHR) inhibitor used in research to downregulate advillin (AVIL) expression. It serves as a valuable tool for investigating AHR signaling in oncology research, with applications in both in vitro and in vivo studies exploring potential anti-cancer mechanisms.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1332084-64-6
• MW: 326.44
• Purity: 99.98% (May vary between batches)
• Formula: C₁₉H₂₆N₄O
• SMILES: C(CCC1=CC=CC=C1)C2(CO)CN(CCC2)C3=NC(N)=NC=C3
• Target: Others,Arp2/3 Complex
• Solubility: DMSO:50 mg/mL (153.17 mM)

Bioactivity

• In Vitro:
  METHODS: U87 cells and astrocytes were treated with PLH1215 (0-80 µM) for 3 days and cell viability was determined by MTT assay. RESULTS: The majority of U87 cells were eliminated with the compound PLH1252 at less than 1 mM, while no significant effect was seen in astrocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PLH 1215, PLH1215, PLH-1215, 1(2Amino4pyrimidinyl)3(3phenylpropyl)3piperidinemethanol(ACI)

Compound Identifiers

PubChem CID

56750508