Platycodin D3

SKU: orb1297235

Description

Platycodin D3 is a natural saponin with NF-κB inhibitory activity, studied for its role in regulating airway mucin and immune cell proliferation in pulmonary inflammation models. It also demonstrates anti-viral activity against Hepatitis C virus in vitro.

Research Area

Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 67884-03-1
• MW: 1387.46
• Purity: 99.84%
• Formula: C₆₃H₁₀₂O₃₃
• SMILES: CC1OC(OC2C(O)C(O)COC2OC(=O)C23CCC(C)(C)CC2C2=CCC4C5(C)CC(O)C(OC6OC(COC7OC(CO)C(O)C(O)C7O)C(O)C(O)C6O)C(CO)(CO)C5CCC4(C)C2(C)CC3O)C(O)C(O)C1OC1OCC(O)C(OC2OCC(O)(CO)C2O)C1O
• Target: HCV Protease,NF-κB
• Solubility: DMSO:60 mg/mL (43.24 mM)

Bioactivity

• In Vitro:
  The aim of this study was to evaluate the functional effects of triterpenoid saponins contained in the root extract of Platycodon grandiflorum (PG) on viral enzyme activities and replication in both HCV replicon cells and cell culture grown HCV- (HCVcc-) infected cells. Inhibitory activities of triterpenoid saponins from PG were verified by NS5B RNA-dependent RNA polymerase assay and were further confirmed in the context of HCV replication. Six triterpenoid saponins (platycodin D, platycodin D2, Platycodin D3, deapioplatycodin D, deapioplatycodin D2, and platyconic acid A), PG saponin mixture (PGSM), were identified as active components exerting anti-HCV activity. Importantly, PGSM exerted synergistic anti-HCV activity in combination with either interferon- α± or NS5A inhibitors.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HCV Protease, HCVProtease, HCV, Hepatitis C virus, inhibit, NF-κB, NF-kB, NFκB, NFkB, Platycodin D 3, Platycodin D3, Platycodin D-3

Compound Identifiers

PubChem CID

75251137