PLAGL2-IN-1

SKU: orb3174272

Description

PLAGL2-IN-1 is an inhibitor of pleomorphic adenoma gene-like 2 (PLAGL2) with a dissociation constant (Kd) of 2.23 µM. This compound suppresses the transcriptional activity of PLAGL2, induces G0/G1 cell cycle arrest and apoptosis, thereby inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. It disrupts extracellular matrix structure and inhibits the PI3K-AKT signaling pathway by reducing AKT phosphorylation levels. Additionally, PLAGL2-IN-1 inhibits tumor growth in HCCLM3 xenograft mouse models and is applicable for research in hepatocellular carcinoma.

Key Properties

• CAS Number: 3099026-16-8
• MW: 632.6
• Formula: C₃₀H₃₅Cl₂N₅O₄S
• SMILES: O=C(C1=CC=C(C(=C1)NS(=O)(=O)C=2C=CC=3C=CC=CC3C2)N4CCN(CC4)C(C)C)N5CCN(C(=O)C(Cl)Cl)CC5
• Target: PI3K,Akt,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Akt,Apoptosis