PKM2-IN-12

SKU: orb3173770

Description

PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. It effectively hinders the proliferation and migration of COLO-205 cells, induces cell cycle arrest, and triggers apoptosis (apoptosis). PKM2-IN-12 significantly reduces lactate, pyruvate, and ROS levels in cells. In mouse models, it not only directly targets cancer cells but also restores disrupted intestinal microecological balance. PKM2-IN-12 is useful for colorectal cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• Target: Endogenous Metabolite,ROS,PKM,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Endogenous Metabolite,ROS,PKM,Apoptosis