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PKM2-IN-11

SKU: orb3173531

Description

PKM2-IN-11 is a PKM2 inhibitor with an IC50 value of 0.363 μM. It operates through dual mechanisms, inhibiting pyruvate kinase M2 (PKM2) and stabilizing microtubules. This compound reduces PKM2 protein levels in MCF-7 cells, slightly decreases reactive oxygen species (ROS) levels, and significantly increases early apoptosis in cells. Additionally, PKM2-IN-11 induces G2/M phase arrest and is applicable in breast cancer research.

Images & Validation

Key Properties

TargetROS,Apoptosis,PKM,Microtubule Associated

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information