PKG drug G1

SKU: orb1302674

Description

PKG drug G1

Research Area

Signal Transduction

Key Properties

• CAS Number: 374703-78-3
• MW: 257.31
• Purity: 97.57%
• Formula: C₁₃H₁₁N₃OS
• SMILES: Cc1[nH]c2ccccc2c1\C=C1/NC(=S)NC1=O
• Target: PKA
• Solubility: DMSO:16.67 mg/mL (64.79 mM)

Bioactivity

• In Vivo:
  The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys the metabolism of Asimadoline is rapid and appears similar in animals and man. Asimadoline has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels
• Animal Research:
  Mice constitutively expressing PKG Iα Cys42Ser are generated on a pure C57BL/6 background. Age-matched and Body weight–matched WT or PKG Iα Cys42Ser KI Male mice are used in All studies. Blood pressure and heart rate are. assessed by radio telemetry in conscious freely moving mice. Alzet osmotic mini-pumps are used to deliver. Angiotensin II at 1.1 mg/kg per day in some studies. PKG drug G1 is delivered intraperitoneally (3.7-14.8 mg/kg) or. orally (20 mg/kg) in some studies. To deliver PKG drug G1 orally, without stress or risk of dislodgin the telemetric. probe catheter, it is provided suspended in water and set in gelatin flavored with sodium saccharin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PKG drug G1, PKG drug G-1, PKG drug G 1, PKG

Compound Identifiers

PubChem CID

928147