PKCiota-IN-2

SKU: orb1685200

Description

PKCiota-IN-2 is a potent and selective small molecule inhibitor of protein kinase C iota (PKC-ι), exhibiting an IC50 of 2.8 nM. It shows weaker activity against PKC-α and PKC-ε. This compound is a valuable research tool for studying PKCι signaling in cancer biology and tumorigenesis, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2230055-52-2
• MW: 395.46
• Purity: 99.74% (May vary between batches)
• Formula: C₂₄H₂₁N₅O
• SMILES: O(C)C1=C(C2=C3N(N=C2)C=CC(=C3)C4=C5C(=NC=C4)NC=C5)C=C6C(=C1)CCNC6
• Target: PKC
• Solubility: DMSO:60 mg/mL (151.72 mM)

Bioactivity

• Target IC50:
  PKCα:71 nM|PKCι:2.8 nM|PKCε:350 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKCiota-IN-2, PKCiota-IN-49, PKC-ι

Compound Identifiers

PubChem CID

138393053