PK-11195

SKU: orb1706786

Description

PK 11195 (RP 52028) is a TSPO ligand widely used in neuroimaging research. It demonstrates protective effects against CoCl2-induced cellular alterations and serves as a tool compound in the study of diseases such as leishmaniasis in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 85532-75-8
• MW: 352.86
• Purity: >98%
• Formula: C₂₁H₂₁ClN₂O
• SMILES: CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
• Target: Parasite
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  L. braziliensis:3.5 μM|L. major:8.2 μM|L. amazonensis:14.2 μM
• In Vitro:
  PK11195 (0.2-400 μM; 48h) exhibits in vitro antileishmanial activity against Lactobacillus amazonicus.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L. amazonensis, L. braziliensis, L. major, Parasite, PK11195, PK-11195, PK 11195, RP52028, RP-52028, RP 52028

Compound Identifiers

PubChem CID

1345