PJ27

SKU: orb3211248

Description

PJ27 is a dual PD-1/PD-L1/JAK1 inhibitor, exhibiting an IC50 of 414 nM for PD-1/PD-L1 and 786 nM for JAK1, with a Ka of 294 nM for human PD-1/PD-L1 and 473 nM for murine PD-1/PD-L1. It facilitates the infiltration of CD3+CD8+ and CD3+CD4+ cells into the tumor microenvironment, enhancing immune activation. In an LLC lung cancer mouse model, PJ27 shows a dose-dependent inhibition of tumor growth and is applicable for studies related to lung cancer.

Key Properties

• Target: PD-1/PD-L1,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,JAK