Pizotifen Malate

SKU: orb1224829

Description

Pizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.

Key Properties

• CAS Number: 5189-11-7
• MW: 429.53
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁NS·C₄H₆O₅
• SMILES: OC(=O)C=CC(O)=O.CN1CCC(CC1)=C1C2=C(CCC3=CC=CC=C13)SC=C2
• Target: 5-HT Receptor
• Solubility: DMSO: 21 mg/mL (48.89 mM)

Bioactivity

• In Vivo:
  The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate); the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.
• In Vitro:
  Pizotifen malate (BC-105 malate)is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. Pizotifen is an antidepresent 5-HT2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor