Piroxicam

SKU: orb1310318

Description

Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drug (NSAID) that functions as a non-selective cyclooxygenase (COX) inhibitor. It is widely used in research to study inflammation, pain, and fever mechanisms in both in vitro biochemical assays and in vivo animal models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 36322-90-4
• MW: 331.35
• Purity: >98%
• Formula: C₁₅H₁₃N₃O₄S
• SMILES: OC=1C=2C(S(=O)(=O)N(C)C1C(NC3=CC=CC=N3)=O)=CC=CC2
• Target: COX (Cyclooxygenase)
• Solubility: Ethanol:1 mg/mL (3.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.04 mM);DMSO:45 mg/mL (135.81 mM)

Bioactivity

• Target IC50:
  COX-2 (human monocyte):25 μM|COX-1:47 μM
• In Vivo:
  Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. Piroxicam increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. Piroxicam up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. Piroxicam combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. Piroxicam inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and Piroxicam does not have any direct cytotoxic effects in vitro. Piroxicam also binds strongly to plasma proteins and Piroxicam could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. Piroxicam prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats.
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• In Vitro:
  Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. Piroxicam and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, CP16171, CP-16171, CP 16171, Cyclooxygenase, COX, Piroxicam

Compound Identifiers

PubChem CID

54676228