Pirinixic Acid

SKU: orb1305848

Description

Pirinixic Acid

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 50892-23-4
• MW: 323.8
• Purity: 99.92%
• Formula: C₁₄H₁₄ClN₃O₂S
• SMILES: N(C1=NC(SCC(O)=O)=NC(Cl)=C1)C2=C(C)C(C)=CC=C2
• Target: PPAR
• Solubility: DMSO:255 mg/mL (787.52 mM)

Bioactivity

• Target IC50:
  PPARγ:32 μM (EC50)|PPARα:1.5 μM(EC50)
• In Vivo:
  WY14643 ( 50 μM) significantly reduce the expression levels of VCAM-1, lowering it to 52% of those in human endothelial cells stimulated by TNF-α. At a concentration of 10 μM, WY 14643 acts on aortic smooth musclee cells to almost completely inhibi the production of IL-6 and prostag andin induced by IL-1, as well a the expression of cyclooxygenase-2, throug the suppression o the NF-κB signaling pathway. Pre-treating endothelial cells with WY 14643 (10 μM) before TNF-α stimulation decreases U937 cell adhesion by 50%.
• In Vitro:
  WY14643 significantly reduced visceral fat mass and total liver triglyceride content without increasing body weight. It enhanced systemic Insulin sensitivity and improved insulin-mediated skeletal musclee glucose metabolism In both red (47%) and white (63%) musclee fibers, as well as in white adipose tissue (90%), while reducing musclee triglyceride and LCACoA accumulation. Administration of WY14643 (1 mg/kg i.v.) 30 minutes before left anterior descending artery occlusion led to a notable reduction in infarct size (~44%) in rats subjected to myocardial ischemia (25 minutes) followed by reperfusion (2 hours). In rats fed a high-fat diet, treatment with 3 mg/kg WY14643 lowered plasma glucose and triglyceride levels (-16% vs. untreated), leptin (-52%), musclee triglycerides (-34%), and ove All long-chain acyl-coenzyme A (-41%) levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NSC 310038, NSC310038, NSC-310038, PPAR, PPARα, Peroxisome proliferator-activated receptors, Wy 14643, Wy14643, Wy-14643, Pirinixic Acid

Compound Identifiers

PubChem CID

5694