Pipinib

SKU: orb3218141

Description

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitor with an IC50 value of 2.2 μM. Pipinib reduces intracellular PI4P levels and inhibits GLI-mediated transcription as well as the expression of Hedgehog target genes. Pipinib additionally blocks the trafficking of Smoothened to primary cilia. Pipinib is applicable to investigations involving basal cell carcinoma, medulloblastoma, Hedgehog signaling, and phosphoinositide-associated cellular regulation.

Key Properties

• CAS Number: 2380013-55-6
• MW: 342.42
• Purity: 98.84% (May vary between batches)
• Formula: C₁₇H₁₈N₄O₂S
• SMILES: O=C(OC)C1=CC=C(C=C1)NC2=NC(=NC=3C=CSC32)NC(C)C
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others