Piperazine Erastin

SKU: orb1307870

Description

Piperazine erastin is an erastin analog that induces ferroptosis, an iron-dependent, non-apoptotic form of cell death. It is widely used as a research tool in vitro and in vivo to study ferroptosis mechanisms, cancer biology, and neurodegenerative diseases.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1538593-71-3
• MW: 645.19
• Purity: 99.52% (May vary between batches)
• Formula: C₃₅H₄₁ClN₆O₄
• SMILES: C(C=1N(C(=O)C=2C(N1)=CC=CC2)C3=C(OC(C)C)C=CC(CN4CCNCC4)=C3)N5CCN(C(COC6=CC=C(Cl)C=C6)=O)CC5
• Target: Ferroptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.1 mM);DMSO:132.5 mg/mL (205.37 mM)

Bioactivity

• In Vivo:
  A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration.
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• In Vitro:
  Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Piperazine Erastin, Ferroptosis

Compound Identifiers

PubChem CID

72710858