Pinostrobin

SKU: orb1297238

Description

Pinostrobin is a neuroprotective flavonoid shown to mitigate Aβ(25-35)-induced toxicity in PC12 cells. Its mechanism involves reducing oxidative stress, preventing calcium overload, and inhibiting mitochondrial apoptosis. This compound is a valuable research tool for studying neuroprotection in models of Alzheimer's disease and related oxidative stress paradigms.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 480-37-5
• MW: 270.28
• Purity: 99.55% (May vary between batches)
• Formula: C₁₆H₁₄O₄
• SMILES: O=C1C=2C(O[C@@H](C1)C3=CC=CC=C3)=CC(OC)=CC2O
• Target: Interleukin,Serine/threonin kinase,Serine Protease,TNF,IL Receptor,HSV,Apoptosis,Beta Amyloid
• Solubility: DMSO:60 mg/mL (221.99 mM)

Bioactivity

• In Vitro:
  Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, cholesterol, BetaAmyloid, anti-cancer,neuroprotective, anti-inflammatory, anti-oxidant, bAmyloid, b Amyloid, PCSK9, inhibit, foxO3a, Inhibitor, IL Receptor, ILReceptor, βAmyloid, β Amyloid, Pinostrobin, TNF-α, Ser/Thr Protease, Serine endopeptidases, Serine kinase, Serine proteases, Threonine proteases, threoninkinase, threonin kinase, Serinekinase

Compound Identifiers

PubChem CID

73201